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Methylation

Methylation

Methylation is probably one of the most important and least understood of all biochemical processes in the body. The first problem is the name itself: “methylation”. It is accurate, of course, but only familiar to organic chemists. A methyl group is a carbon molecule with three hydrogen molecules attached “–CH3”. Anytime your body wants to add a carbon molecule to some compound it engages in methylation. The body requires vitamins Folic Acid, B12, B2, and B6 for methylation to occur efficiently. The process is so important to health that the body has a back up methylation system in reserve using tri-methyl glycine (TMG), also known as betaine. 

Methylation is essential for

  • DNA synthesis and cell replication
  • Cell differentiation (making a liver cell instead of a lung cell and also preventing a liver cell from becoming cancerous)
  • All neurotransmitter synthesis (brain chemistry)
  • Nerve myelination
  • Carnitine synthesis (fat metabolism and heart health)
  • Detoxification

If you do not have adequate methylation capacity, your risk of many diseases increases up to 300%

  • Heart Disease, Heart Attack, Stroke
  • Senility and Alzheimer’s Disease
  • Depression
  • Birth defects in foetuses especially to the neural tube and palate
  • Type-2 Diabetes
  • Deep Vein Thrombosis
  • Osteoporosis
  • Rheumatoid Arthritis
  • Breast, Prostate and Colon Cancer

In reality, problems with methylation arise only from functional deficiencies of those vitamins that drive methylation: Folic Acid, B12, B2, and B6. Inadequate methylation is usually identified through a laboratory test looking for elevations in plasma homocysteine, but organic and amino acid imbalances in the urine (ONE Profile) can also identify problems with methylation.

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